Association of childhood BMI trajectory with post-adolescent and adult lung function is mediated by pre-adolescent DNA methylation

Abstract Background Body mass index (BMI) has been shown to be associated with lung function.Recent findings showed that DNA methylation (DNAm) variation is likely to be a consequence of changes in BMI.However, whether DNAm mediates the association of BMI with lung function is unknown.We examined the mediating role of DNAm on the association of pre

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Quantifying the Metabolic Signature of Multiple Sclerosis by in vivo Proton Magnetic Resonance Spectroscopy: Current Challenges and Future Outlook in the Translation From Proton Signal to Diagnostic Biomarker

Proton magnetic resonance spectroscopy (1H-MRS) offers a growing variety of methods for querying potential diagnostic biomarkers of multiple sclerosis in living central nervous system tissue.For the past three decades, 1H-MRS has enabled the acquisition of a rich dataset suggestive of numerous metabolic alterations in lesions, normal-appearing whit

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